Acquisition of testosterone treatment NebidoTM from Bayer

This is an observational study with a drug called Nebido, a new testosterone replacement therapy, which is available for the GHRP 2 pharmacy treatment of male hypogonadism. The benefit and safety of Nebido have already been thoroughly evaluated through well controlled clinical trials. The main purpose of this observational study is to confirm the established safety profile of Nebido in daily clinical practice. Male hypogonadism due to a reduced or absent secretion of testosterone from the testes is characterized by clinical symptoms such as low libido, erectile dysfunction, asthenia, small testes and decreased muscle mass. These symptoms are sometimes misinterpreted as signs of stress and ageing. In addition to physical symptoms, there can also be psychological symptoms, including depression.

Muscle building and drug tests

The solution for intramuscular injection is to be visually inspected prior to use and only clear solutions free from particles should beused. Following the use of hormonal substances such as androgen compounds, cases of benign (non-cancerous) and malignant (cancerous) liver tumours have been observed to occur. You will not be prescribed Nebido if you have ever had a liver tumour (see “Do not use Nebido”). Men with ED and low T may also benefit from TU administration, and the combination of phosphodiesterease 5-inhibitors and TU may be indicated in men who do not respond sufficiently to phosphodiesterease 5-inhibitors alone. The medication is used to treat men with low or no testosterone due to medical conditions such as hypogonadism.

If your liver is not working

Your doctor will inject Testosterone Undecanoate (1 vial) very slowly into a muscle. This is enough to maintain sufficient testosterone levels without leading to a build-up of testosterone in the blood. Improvement in scores on the international index of erectile function (IIEF) in 71 of 122 patients receiving treatment with long-acting testosterone undecanoate. Disappearance of venous leakage evidenced by cavernosography in a hypogonadal man with erectile dysfunction at baseline (left) and after 3 months’ administration of testosterone undecanoate (right). Before you start Nebido injections, there are some steps to take with your medical team. First, your doctor will have to take a testosterone blood sample to measure the amount of testosterone and other contents in the blood.

• It is important that you stay in communication with your medical professionals and you notify them if you are having any negative side effects.
• Before your doctor injects Testosterone Undecanoate, he/she will examine you to check that you do not have prostate cancer.
• Maintaining your Testosterone Undecanoate levels during treatment The injection interval should always be within the recommended range of 10 to 14 weeks.
• There is a new interest in the treatment of erectile dysfunction with testosterone.
• The effects of T are mediated directly as testosterone or after conversion to either 5α DHT or estradiol locally in target tissues.
• A parallel increase of 17β-estradiol levels was seen, but there was an earlier decrease to pre-treatment levels by 4-weeks after the last injection.

Serum LH and FSH were suppressed during the treatment period, while sex hormone binding globulin (SHBG) remained stable. The latter is probably an expression of the physiological range of achieved plasma testosterone levels; administration of high dose testosterone leads to a fall in plasma SHBG levels (Anderson et al 1996). After a recommended loading dose of two injections at a 6-week interval, TU is the first intramuscular agent that can be administered every 12-weeks thus maintaining physiological plasma T levels.

To do this, you’ll be seeing your medical professional who will be administering your treatment every weeks for the best results. During this time, your doctor will continue to take tests and determine the amount of testosterone in the blood. They will determine if there is enough during this time and if adjustments need to be made in your dosage amount or frequency. During the maintenance stage, you should bring up any concerns or questions that you have about your treatment so that they can be addressed by your medical professional.